3 edition of Tumor antigens recognized by T cells and antibodies found in the catalog.
Tumor antigens recognized by T cells and antibodies
Includes bibliographical references and index.
|Statement||edited by Hans J. Stauss, Yutaka Kawakami and Giorgio Parmiani.|
|Series||Tumor immunology and immunotherapy series -- v. 3|
|Contributions||Stauss, Hans J. 1956-, Kawakami, Yutaka., Parmiani, Giorgio.|
|LC Classifications||QR188.6 .T847 2003|
|The Physical Object|
|Pagination||xviii, 201 p. :|
|Number of Pages||201|
With the recent developments of adoptive T cell therapies and the use of new monoclonal antibodies against the immune checkpoints, immunotherapy is at a turning point. Key players for the success of these therapies are the cytolytic T lymphocytes, which are a subset of T cells able to recognize and kill tumor cells. Here, I review the nature of the antigenic peptides recognized by these T Cited by: Human Cancer Biology Efﬁcient Identiﬁcation of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions Yong-Chen Lu 1, Xin Yao, Jessica S. Crystal, Yong F. Li, Mona El-Gamil1, Colin Gross1, Lindy Davis1, Mark E. Dudley 1, James C. Yang, Yardena Samuels2, Steven A. Rosenberg1, and Paul F. Robbins1 AbstractCited by:
Preclinical animal studies have convincingly demonstrated that tumor immunity to self antigens can be actively induced and can translate into an effective anti-tumor response. Several of these observations are being tested in clinical trials. Immunization with xenogeneic DNA is an attractive approach to treat cancer since it generates T cell and antibody by: The question of whether human tumors express antigens that can be recognized by the immune system has been answered with a resounding YES. Most were identified through spontaneous antitumor humoral and cellular immune responses found in cancer patients and include peptides, glycopeptides, phosphopeptides, viral peptides, and peptides resulting from common mutations in Cited by:
We previously identified the aberrantly expressed cell cycle regulator cyclin B1 as a tumor antigen recognized by antibodies and T cells from patients with breast, lung, and head and neck cancers. Ordinarily expressed only transiently in the G2/M stage of the cell cycle in normal cells, cyclin B1 is constitutively expressed at high levels in the cytoplasm of these and many other tumor types Cited by: Also, some tumors may shed their antigens which in turn may interact and block antibodies and T cells from reacting with the tumor cells. Use of tumor neo-antigens in patient management. The presence of neo-antigens on tumor cells has been exploited for both .
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Tumor Antigens Recognized by T Cells and Antibodies (Tumor Immunology and Immunotherapy Book 1) - Kindle edition by Giorgio Parmiani, Hans J Stauss, Yutaka Kawakami, Giorgio Parmiani. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Tumor Antigens Recognized by T Cells and Antibodies (Tumor Price: $ Tumor Antigens Recognized by T Cells and Antibodies provides a comprehensive overview of the molecular nature of tumor antigens that can be recognized by antibodies, helper T lymphocytes and cytotoxic T lymphocytes.
Novel strategies to enhance ineffective immunity against such antigens provide the basis for improved immunotherapy protocols for Format: Hardcover.
Kawakami, Y. et al. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.
Proc. Natl Acad. Sci. Cited by: Tumor Antigens Recognized by T Cells and Antibodies provides a comprehensive overview of the molecular nature of tumor antigens that can be recognized by antibodies, helper T lymphocytes and cytotoxic T lymphocytes. Human Tumor Antigens Recognized by Antibodies (SEREX).
Antibodies to Tumor Oncoproteins in Cancer Patients. Due to availability of new technology, the first gene recognized by T cell, was reported to encode a human tumor antigen and then rapidly molecular identification and characterization of novel tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs) including shared antigens, neoantigens, and unique antigens was developed.
Recent progress in fundamental tumor immunology has led to immunotherapy trials in patients with solid tumors and hematological malignancies. In the past, immunotherapy approaches were primarily based on enhancement of tumor immunity with cytokines and adjuvant therapy, without knowledge of relevant tumor by: 6.
Mouse models Tumor antigens recognized by T cells and antibodies book the recognition of tumour antigens / Vito R. Cicinnati, Susanne Beckebaum and Albert B. Deleo --Role of heat shock protein in chaperoning tumor antigens and modulating anti-tumor immunity / Zihai Li --WT1 as target for tumor immunotherapy / Hans J.
Stauss [and others] --Human melanoma antigens recognized by CD8+ T cells / Yutaka. For antigens recognized by T cells, isolation and cloning of tumor-infiltrating T cells has facilitated identification of expressed tumor-derived peptides that have apparently induced a local response (Rosenberg, ).
Glycoprotein antigens may be expressed at the surface of the tumor cell, or be secreted, while the peptides will be bound to.
Tumor Antigens Recognized by Antibodies. Human Tumor Antigens Recognized by Antibodies (SEREX). Antibodies to Tumor Oncoproteins in Cancer Patients. Antibody and CTL Responses to the NY-ESO Antigen. Tumor Antigens Recognized by CD4+ T Cells (predominantly TH1). Melanoma Antigens Recognized by CD4+ T Cells.
recognize tumour-specific antigens. The first human tumour-specific antigens that were recognized by T cells were discovered about 20 years ago (FIG. 1 (TIMELINE)). Considering the increasing number of clinical studies that rely on the presence of tumour-specific antigens that are recognized by T cells, it is.
from book General principles while some tumor antigens may be recognized by T cells or antibodies, we will focus on the antigens recognized by T cells, the primary immune effector for. T-cells play an important role in in vivo tumor rejection in many animal tumor models and in human melanoma.
Many human tumor antigens recognized by autologous T-cells have now been identified. These are found to be nonmutated and mutated peptides derived Cited by: Get this from a library. Tumor antigens recognized by T cells and antibodies. [Hans J Stauss; Yutaka Kawakami; Giorgio Parmiani;] -- Providing a comprehensive overview of the molecular nature of tumor antigens, this book provides invaluable information for all clinicians and researchers with an interest in cancer immunotherapy.
In book: eLS. Cite this publication Tumour Antigens Recognized by Antibodies. and histo-blood group related carbohydrates on the surface of tumor cells has resulted in several of these. The term “tumor antigen” has been given a new and much more precise definition as a result of important developments in immunology over the last decade, particularly in the area of antigen presentation and antigen recognition.
For something to be a tumor antigen, it must be recognized by specific immune effector cells and/or antibodies and be produced by tumor cells. Hammersmith Hospital, London, UK. Text provides a comprehensive overview of the molecular nature of tumor antigens recognized by antibodies, helper T lymphocytes, and cytotoxic T lymphocytes.
Provides the basis for improved immunotherapy in cancer treatment. For clinicians and researchers. DNLM: Antigens, Neoplasm. Tumor antigens recognized by T cells.
Abstract. A large number of human tumor-specific antigens have been identified. Here, Thierry Boon and colleagues explain that the priority now is to demonstrate that immunization against them is clinically valuable. References. Sahin by: While target antigens in the form of surface proteins or carbohydrates that may be recognized by antibodies had been well accepted for quite some time, it was not until observations on the MHC-restricted killing of tumor cells by cytolytic T cells, that attempts were made to clone the genes that encoded the antigens recognized by the T cells.
Buy Tumor Antigens Recognized by T Cells and Antibodies (Tumor Immunology) 1 by Hans J Stauss, Yutaka Kawakami, Giorgio Parmiani (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders. Abstract.
Much has been learned since the realization that anti-tumor cytotoxic T lymphocytes (CTL), which constitute the major effectors involved in tumor rejection, can be cultured in vitro and used as tools to identify the target antigens expressed by the tumor cells (reviewed by Boon et al.
1).Tumor-specific CTL have been obtained in most mouse tumor models and in several human tumor types Cited by: 1. Human tumor antigens recognized by T cells have been identified by means of various molecular biological and immunological methods, including cDNA expression cloning with patients’ T cells and antibodies, cDNA subtraction using RDA and PCR differential display, systematic gene analysis such as DNA sequencing, CGH,Cited by: Malignant cells can be specifically recognized by T lymphocytes or antibodies in cancer patients.
This specificity is mediated by the somatically rearranged antigen-receptors in T cells and B cells, i.e., the T cell receptor alpha and beta chains and the immunoglobulin light and heavy chains.T cell epitope cloning: Many antigens recognized by CD8+ T cells have been identified by transfecting cDNA libraries from tumor cells into target cells expressing the appropriate HLA molecule, and then using anti-tumor T cells isolated from tumor infiltrates (TILs) to identify the antigen epitopes presented by HLA on the surface of cDNA libraries-File Size: KB.